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Chromatin is organized in a
highly ordered yet dynamic manner in the cell nucleus, but the principles
governing this organizationremain unclear. Similarly, it
is unknown whether, and how, various proteins regulate chromatin motion
and as a result influence nuclear organization. Here by studying the
dynamics of different genomic regions in the nucleus of live cells, we show
that the genome has highly constrained dynamics. Interestingly, depletion of
lamin A strikingly alters genome dynamics, inducing a dramatic transition from
slow anomalous diffusion to fast and normal diffusion. In contrast, depletion
of LAP2α, a protein that interacts with lamin A and chromatin, has no such
effect on genome dynamics. We speculate that chromosomal inter-chain
interactions formed by lamin A throughout the nucleus contribute to
chromatin dynamics, and suggest that the molecular regulation of chromatin
diffusion by lamin A in the nuclear interior is critical for the
maintenance of genome organization.
(PDF grátis: Nature Communications)
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