Understanding
genetic regulation is a problem of fundamental importance. Recent studies have
made it increasingly evident that, whereas the cellular genetic regulation
system embodies multiple disparate elements engaged in numerous interactions, the
central issue is the genuine function of the DNA molecule as information
carrier. Compelling evidence suggests that the DNA, in addition to the digital
information of the linear genetic code (the semantics), encodes equally
important continuous, or analog, information that specifies the structural
dynamics and configuration (the syntax) of the polymer. These two DNA
information types are intrinsically coupled in the primary sequence
organisation, and this coupling is directly relevant to regulation of the
genetic function. In this review, we emphasise the critical need of holistic
integration of the DNA information as a prerequisite for understanding the
organisational complexity of the genetic regulation system.
Nota do blog Desafiando a Nomenklatura Científica: “O DNA é irredutivelmente
complexo? Há mais de duas décadas quem vem afirmando a informação complexa
especificada digitalizada do DNA? Quem? Quem mesmo? Ah, a turma da teoria do
Design Inteligente. Mas eles não sabem o que é ciência nem fazem ciência...”
